Primary Anorectal Malignant Melanoma (PARM) with Liver Metastasis: Case Report

Abstract

Primary Anorectal Malignant Melanoma (PARM) is a rare and aggressive tumor with incidence of 3% of all anorectal cancers. The tumor may seem like adenocarcinomas, small cell carcinomas, or sarcomas histologically, yet it looks like hemorrhoids grossly. It is frequently discovered at an advanced stage due to vague symptoms and its aggressive nature, resulting in a bad prognosis. The prognosis is poor, with a median survival of only 24 months and a 5-year survival rate of < 10%. The majority of patients die as a result of complications related to metastasis. We are reporting a case of 57year old woman with PARM with liver metastasis. The diagnosis of primary anorectal malignant melanoma can be challenging due to its rarity and the overlap of symptoms with other more frequent anorectal diseases. This case study emphasizes the significance of including malignant melanoma in the differential diagnosis of anorectal malignancies. The occurrence of liver metastases highlights the disease's aggressive nature and the importance of a comprehensive diagnostic approach. The treatment options for anorectal melanoma with liver metastases are limited and generally palliative, with the goal of enhancing quality of life and prolonging life expectancy.