Vortex and Crater-Squamous Cell Carcinoma Lung

Abstract

Squamous cell carcinoma lung manifests as a malignant tumefaction emerging from epithelial cells demonstrating squamous differentiation. Squamous epithelial differentiation within the neoplasm is represented by morphological features as variable proportion of intercellular bridges, focal intracellular or extracellular keratinization and configuration of keratin pearls, cogent immunohistochemistry may be advantageously applied for diagnostic confirmation. Squamous cell carcinoma lung may appear as keratinizing or non-keratinizing neoplasm. Additionally, diverse subtypes as solid, cystic, papillary, pseudo-glandular, alveolarfilling or sarcomatoid with spindle shaped cells may be observed. In contrast, poorly differentiated neoplasms appear devoid of cogent morphological features indicative of squamous differentiation.