Evidence of Complement Decay-Accelerating Factor Transmembrane Isoform Gene of Complement Factor B of Complement Factor H Genes in the Sea Star Asterias Rubens: Three Regulators of Complement Pathways

Abstract

The main components of Complement (alternative and direct pathway genes)correlated with mammal genes were
discovered in the sea star genome. CR receptor gene was also found. We describe now the complement decayaccelerating factor transmembrane isoform gene: a regulator gene of Complement cascade. How genes are expressed?
By which pathway? The presence of this last gene seems to indicate the direct pathway.But , on the other hand,
Complement factor B gene was discriminated so that complement factor H gene in sea star genome, and these genes
are implicated in alternative pathway. We may envisage that the two pathways co-exist in sea star immune response
which leads to the formation of the sea star primitive antibody