Antihyperlipidemic and Antibacterial Activities of Baccaurea Courtallensis Leaves

Abstract

The present study evaluated the antihyperlipidemic and antibacterial activities of B. courtallensis extract. The antihyperlipidemic effect of B. courtallensis methanol extract was studied in Triton WR-1339 and high fat diet–induced hyperlipidemic rats. In Triton WR-1339 and high fat diet-induced hyperlipidemic rats, B. courtallensis (200 and 400 mg/kg) exerted a significant (P ≤ 0.05, P ≤ 0.01, P ≤ 0.001) alteration in serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) to near normal. The antibacterial activity of B. courtallensis was evaluated by agar-well diffusion method against selected gram negative bacteria: Bacillus subtilis, Pseudomonas aeruginosa and gram positive bacteria: Staphylococcus aureus, Escherichia coli. B. Courtallensis extract exhibited pronounced activity against all the bacterial strains tested and the activity was comparable to the standard drug Amoxicillin (100 μg/ml). The results of the present study demonstrate that the methanolic extract of B. courtallensis possess antihyperlipidemic and antibacterial activities.