Diclofenac Sodium Loaded Nanosized Ethosomes: An Investigation on Z-Average, Polydispersity and Stability

Abstract

Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID). Oral therapy with NSAID is always associated with several side effects such as gastric bleeding, and ulceration. The purpose of this work was to explore the feasibility of power ultrasound in designing a noval ethosomal carrier based on Phosphatidyl choline (PC) and ethanol for topical application of Diclofenac sodium, and further to investigate Z-Average (nm), polydispersity index (PDI) and zeta potential (mV). The designed drug loaded ethosomes had Z-Average of 440.3nm, PDI of 0.56, and zeta potential of -35.2 mV. The obtained results demonstrated feasibility of power ultrasound in achieving nanosized drug loaded ethosomes though PDI value (above 0.5) was clearly indicative of broad distribution of particles. The zeta potential value of -35.2 mV substantiated stability of Diclofenac sodium loaded ethosomes.