An Updated Review on Self Emulsifying Drug Delivery System

Abstract

Solubility of orally administered drug is major obstacle of pharmaceutical industry as nearly 35-40% of newly discovered drugs substancehave low aqueous solubility which results in their poor dissolution and bioavailability, which results in high intra & inter subject variations & lack of dose proportionality. The dissolution and bioavailability of drug substances can be enhanced by various methods like salt formation, solid dispersion and complexion. Self-Emulsifying Drug Delivery System (SEDDS) is getting popularity for enhancing solubility of lipophilic drugs. SEDDS is a combination of aqueous solvents and co-solvents/surfactants that have an ability of forming fine oil-in-water (o/w) micro emulsions upon gentle agitation after dilution in aqueous media, such as GI fluids. This review provides an updates in the advancements in SEDDS with regard to its composition, evaluation, and also various pharmaceutical applications.