Co-Administration of PLGA Nano-Boldine Can Reduce Cisplatin- Induced Toxicity in Normal Tissue of Cancer Mice Model: A Commentary on Our Published Research

Abstract

The greatest problem of using some potent anti-cancer drugs in cancer patients is its cytotoxicity to normal tissue when the cancer tissue is targeted for annihilation, often producing unwanted side-effects, and thereby restricting its effective and prolonged use in cancer patients. Therefore, one solution for such a problem could be to try to potentially reduce if not totally eliminate such side-effects often resulting from damage to normal healthy tissue. In this commentary, an attempt will be made to focus on the salient results obtained in our earlier representative study [1] primarily aimed at examining if co-administration of poly (lactide-co-glycolide) (PLGA)-nanoparticles loaded Boldine, an antioxidant ingredient of ethanolic extract of Boldo plant (Peumus boldus) could reduce unwanted Cisplatin-(a potent chemotherapeutic drug)-induced toxicity in normal tissue of cancer mice model, Mus musculus, which could be extrapolated in human cases of cancer.