Rare Cases of Primary Glioblastoma Multiforme in the Cervical Spinal Cord, Report of Two Cases and Literature Review

Abstract

Glioblastoma multiforme (GBM) is a highly aggressive and malignant tumor that can arise in the central nervous system, including the spinal cord. We presented two cases of GBM in spinal cord and cerebellum, respectively. First, 36-year-old female who presented to our clinic with a two-month history of progressive lower and upper extremities weakness and numbness. He also reported difficulty with urination and defecation. Second patient was 19 years-old-man with history of extremities weakness and neck pain. MRI demonstrated enhanced intra-medullary tumor in cervical spine. Both patients underwent surgical resection, followed by radiation therapy and chemotherapy. Further researches are needed to identify optimal treatment strategies and improve outcomes for patients with GBM in the spinal cord. Close monitoring and follow-up care are essential to manage potential complications and optimize quality of life for affected individuals.