Orthodontic Forces Commanding Genes to Cue Teeth in Lines: A Meta Analysis

Abstract

If orthodontic tooth movement is a drama, in the biological theater of PLD, genes are the directors, commands the rest of
the cells of PDL in proper places and align in a single line.
Aims and objectives: The main aim of our study is to understand the generation and propagation of signaling cascades
molecules and associated tissue remodeling in adjacent tissue response to applied mechanical loads from the central
theme of orthodontic tooth movement
Materials and methods: We have searched those original articles, research work, and reviews that are used term genes,
a role of genes in orthodontic tooth movement.
Data collection and analysis: Data was collected with a search on, EBSCO (2010-December); MEDKNOW
(2013December); Ovid MEDLINE(R) (2016), SCOPUS, ELSEVIER, SAGE abstract and citation database.
The Results: Sum of 16 articles was completely meeting the inclusion criteria. Apart from which, none of the relevant
articles were found by our reviewer and expertise. Most commonly discussed topics are Orthodontic Tooth Movement
and ECM Remodeling, Pressure: Tension Related Effects, Cytokines in orthodontic tooth movement, RANK RANKL/OPG
pathway, Role of growth factor, Colony-stimulating factors, and bone morphogenic factor.
Conclusion: Genes like SOX-9 gene, PTHrP and IHH, RANKL, M-CSF, and RANKL –OPG pathways mainly significant in
avoiding ankylosis of tooth within and during orthodontic tooth movement. The supportive to these pathways are of IL-1
α, IL-6, IL-11, TNF- α,) BMP2, BMP7, (TGFβ) and FGF.