MMP-9 Expression in Normal Rabbit Chondrocytes

Authors

  • Hanan H. Abd-Elhafeez* Department of Anatomy, Embryology and Histology, Assiut University, Egypt Author
  • Basma Kamal Department of Anatomy and Embryology, University of Sadat City, Egypt Author
  • Abeera M. El-Sayed Fellow of Sohag University Hospital, Sohag University, Egypt Author
  • Soha A. Soliman Department of Histology, South Valley University, Egypt Author

DOI:

https://doi.org/10.23880/chij-16000131

Keywords:

MMP-9, Chondrocytes, Chondroblasts, Rabbit

Abstract

Chondrocytes regulate anabolic and catabolic processes to maintain the extracellular matrix components. Catabolic activities
depend on the proteolytic action of the matrix -degrading enzymes including ADAMTS (A disintegrin and metalloproteinases)
and MMP (Matrix Metalloproteinase). The current study explored the distribution of MMP-9 in normal articular cartilages
of the embryos rabbit. Articular cartilage has grown by appositional growth that the perichondrial stem cells differentiate
into chondrocytes. MMP-9 positive perichondrial stem cells or chondroblasts and early chondrocytes. Mature chondrocytes
exhibited weak immunoaffinity for MMP-9. In conclusion, MMP-9 was essential during chondrocytes growth. The current
study alludes to the potential role of MMP-9 during the growth of the articular cartilage.

Downloads

Published

2021-04-29

Issue

Vol. 5 No. 1 (2021)

Section

Articles

License

Copyright (c) 2021 Hanan H. Abd-Elhafeez

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.