The Pervasive Forager-Solitary Reticulohistiocytoma

Abstract

Solitary reticulohistiocytoma is an exceptional, benign, non-neoplastic, non-Langerhans histiocytic cell proliferation. The
condition appears as a cytokine-induced, localized collection of histiocytic cells emerging as a reaction to an obscure inflammatory
stimulus. Reticulohistiocytic lesions are subcategorized into distinct categories as solitary cutaneous reticulohistiocytoma,
multiple cutaneous reticulohistiocytoma and multi-centric reticulohistiocytosis. Solitary reticulohistiocytoma appears as
an isolated, painless nodule at diverse sites and is devoid of systemic symptoms. A diffuse, dermal infiltration of enlarged,
mononuclear or multinuclear histiocytic cells is admixed with lymphocytes and foci of dermal fibrosis.