Comparative In Vitro Quality Evaluation of Some Clopidogrel Tablets, Commercially Available in Bangladesh Drug Market

Abstract

Clopidogrel is a potent anti-platelets and antithrombotic drug. It is film coated and 75 mg tablet. The objective of our study was to evaluate the quality parameters of some marketed clopidrogel tablet and to compare the parameters among them. To assess the quality, nine different marketed clopidogrel 75 mg tablet were selected and in-vitro dissolution test, potency, disintegration time were carried out. Other general quality parameters of these tablets like weight variation, hardness, friability were also determined according to established protocols. All the brands comply the requirements of ‘‘United State Pharmacopoeia’’ as they showed acceptable weight variation range. Friability of all brands was less than 1%. No significant differences were founding disintegration time as they disintegrated within 15 minutes. In case of dissolution profile all brands showed better dissolution time as they released more than 75% of drug in 45 minute. The hardness of one brand was within the range 40-60N. The limitation of the potency must be within 95-105%. All three brands meet this specification. This study suggested that most commercially available clopidogrel tablet in Bangladesh maintain the quality and comply with the USP specifications which are essential for better therapeutic activity of these anti-platelet drug.