To Investigate the Neuroprotective Effect of Crocin against Colchicine and Aluminium Chloride Induced Cognitive Disfunction and Oxidative Damage in Rodents

Abstract

Neuroprotective effect of Crocin against intracerebral administration of Colchicine induced neurotoxicity in mice has been studied. Effect of Crocin on colchicine induced memory impairment in Morris water maze test was done. Colchicine is a powerful mitotic poison, anti-inflammatory, and inhibitor of tumor growth. Most biological effects of colchicine are probably related to the formation of a colchicine-tubulin complex which prevents microtubule polymerization. It is used in cancer chemo therapy but is limited due to its high toxicity. The present study showed that intraperitoneal administration of Crocin has neuroprotective effect. It was suggested because of assessing various biochemical and behavioural parameters. In this study two models were taken (colchicine and aluminium chloride induced oxidative damage and cognitive dysfunction) to assess neuroprotective effect of crocin. Neuroprotective action of crocin may be beneficial for the prevention and treatment of Al-induced oxidative damage in the brain. The present study also showed that treatment with crocin ameliorated colchicine-induced memory impairment in mice. Furthermore, the beneficial effects of crocin may be attributed to reduced oxidative stress and cholinergic dysfunction in the brain.