Ferric Nitrilotriacetete Augments 7,12-Dimethylbenz(a) Anthracene-Initiated and Benzoyl Peroxide -Promoted Skin Carcinogenesis

Abstract

Background: Renal cancer is caused by ferric nitrilotriacetete (Fe-NTA), and little is known about its implications on skin cancer. The effects of Fe-NTA on benzoyl peroxide (BPO) -induced tumor stimulation in 7,12-dimethyl benz(a)anthracene (DMBA)-initiated mouse cutaneous carcinogenesis have been presented in this report.

Methods: Fe-NTA was administered topically to Swiss mice, and tumors were induced with DMBA. After that, the animals were given BPO for 40 weeks. The occurrence of tumors was documented. Results: Fe-NTA at a dose of 12 mg iron per mouse induced an increase in tumor occurrence over times as compared to the control (DMBA+ BPO) treated group. Tumors appeared earlier in the Fe-NTA group, with a higher incidence number of tumors. In addition, BPO-mediated lipid peroxide induction and [3H] thymidine uptake were greater in Fe-NTA treated group. Conclusion: We propose that Fe-NTA boosts BPO, tumor-promoting potential, and that Fe-NTA-induced oxidative stress is effective for BPO mediated cutaneous carcinogenesis.