Characteristics and Micromorphology of Designed Regenerative a Cellular Dermal Collagen Particles Derived from a Combined Procedure of Supercritical Carbon Dioxide Fluids and Protease Treatments at Low Temperatures

Authors

  • Ching-Cheng Huang* Department of Biomedical Engineering, Ming-Chuan University, Taoyuan, Taiwan Author
  • Meng-Jen Yang PARSD Pharmaceutical Technology Research Center(PBMRC), Changzhou, Jiangsu Author
  • Guifeng Zhang State Key lab of biochemical engineering, Institute of process engineering, Chinese Academy of Sciences, Beijing Author
  • Xiong xin Lei PARSD Pharmaceutical Technology Research Center(PBMRC), Changzhou, Jiangsu Author

DOI:

https://doi.org/10.23880/aabsc-16000120

Keywords:

Collagen, Morphology, Extra-cellular matrix, ECM

Abstract

A new regenerative collagen particle with extra-cellular matrix (ECM) was designed and prepared from porcine dermal. A specific tissue-cutting machine was designed to prepare extra thin tissue membranes, which could be used for preparing the regenerative collagen particles with ECM. Furthermore, a novel procedure combining supercritical carbon dioxide fluids technology and protease treatments at low temperatures was employed. Characteristics of the resulting regenerative collagen particles with ECM were observed by determining morphology, thermal property and mechanical property for clinic application of medical devices. 

Published

2019-03-22

Issue

Vol. 2 No. 1 (2019)

Section

Articles

License

Copyright (c) 2019 Ching-Cheng Huang

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Characteristics and Micromorphology of Designed Regenerative a Cellular Dermal Collagen Particles Derived from a Combined Procedure of Supercritical Carbon Dioxide Fluids and Protease Treatments at Low Temperatures. (2019). Annals of Advanced Biomedical Sciences, 2(1), 1-4. https://doi.org/10.23880/aabsc-16000120

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