The Effect of Porphyromonas gingivalis on Gut Dysbiosis and Its Possible Association with Orodigestive Cancers

Abstract

The oral microbiota is the microbial community of the oral cavity and is one of the most divergent microbiomes of all the human body. It has an important role in maintaining oral homeostasis [1]. The oral microbiota also plays a part in the pathophysiology of orodigestive cancers [2]. Contributing to the total number of malignancies worldwide, orodigestive cancers include those cancers of the oral cavity and gastrointestinal tract as well as pancreas [3]. The oral microbiome also represents a dynamic biochemical network that is formed by the interaction of proteomes and metabolomes. The hygienic and dietary habits of the host, along with the genetic, behavioral and immunologic host factors also contribute to this formation